Choose Domane if your best rides are measured in hours rather than finish-line seconds. It suits sportives, club runs, long solo loops, quick after-work miles and mixed-surface routes where you still want a proper road-bike feel.
If you want the lowest, most aggressive position and every aero advantage, look towards the Madone. If rough gravel and technical off-road riding are the main event, a dedicated gravel bike will give you more tyre room and stability. Domane sits neatly between them: fast on tarmac, comfortable all day and capable when the road gets scruffy.